5-Amino-1MQ Canada: 10mg NNMT Research Compound
5-Amino-1MQ 10mg is supplied in Canada for laboratory research on 5-amino-1-methylquinolinium, a small-molecule inhibitor used in studies of nicotinamide N-methyltransferase (NNMT). Unlike the peptide materials in much of the Tier One catalog, 5-Amino-1MQ is not a peptide. Published work has examined it primarily as a chemical probe for NNMT activity and for downstream changes in nicotinamide, methyl-donor and metabolic pathways. The evidence base remains preclinical, and Tier One does not make weight-loss, metabolic-treatment or human-use claims.
Quick Research Profile
| Material |
5-Amino-1MQ / 5-amino-1-methylquinolinium |
| Strength |
10mg |
| Research classification |
Small-molecule quinolinium NNMT inhibitor |
| Primary research target |
Nicotinamide N-methyltransferase (NNMT) |
| Research pathways |
Nicotinamide metabolism, 1-methylnicotinamide formation, NAD-related metabolism and methyl-donor balance |
| Literature status |
Cell and animal research; no established human therapeutic efficacy |
| Intended use |
Laboratory research only — not for human or veterinary use |
NNMT Inhibition and Nicotinamide Metabolism
NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide. Because this reaction intersects both nicotinamide handling and cellular methyl-donor metabolism, NNMT has become a research target in metabolic biology. In a widely cited preclinical study, 5-Amino-1MQ was characterized as a membrane-permeable small-molecule NNMT inhibitor. Researchers measured reduced intracellular 1-methylnicotinamide and changes in NAD+ and S-adenosylmethionine-related metabolites in adipocyte models.
These biochemical observations make 5-Amino-1MQ useful as a laboratory probe when the research question concerns NNMT activity rather than as evidence for a consumer outcome. The original literature also included diet-induced-obesity mouse models, but animal findings should not be generalized into human efficacy, safety or treatment claims.
Research Areas
NNMT enzymology: Studies can use 5-Amino-1MQ to investigate NNMT inhibition and the relationship between enzyme activity and 1-methylnicotinamide production.
Nicotinamide and NAD-related pathways: Research has examined how NNMT inhibition changes metabolite pools connected to nicotinamide salvage and cellular energy biology.
Methyl-donor metabolism: Because NNMT consumes S-adenosylmethionine during nicotinamide methylation, inhibition has been studied in relation to SAM/SAH balance and broader methylation biology.
Preclinical metabolic models: Cell and mouse studies have explored adipocyte lipid accumulation, adipose phenotypes and diet-associated metabolic changes. These are experimental findings, not established clinical outcomes.
Evidence Quality and Limitations
The strongest product-specific evidence for 5-Amino-1MQ is preclinical. Published studies include biochemical assays, cultured cells and mouse models. Differences in species, experimental conditions, compound identity, concentration and model design can materially affect results. There is no basis for Tier One to present 5-Amino-1MQ as a proven therapy, weight-loss product, supplement or personal-use material. Researchers should verify the identity and analytical characteristics of the specific batch used in their work.
Selected Research References
References are provided for scientific context. Researchers should review the original methods, material identity, models and limitations before applying published findings to experimental design.
Research FAQ: 5-Amino-1MQ
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small-molecule quinolinium research compound. Tier One categorizes it separately from peptide materials to avoid misrepresenting its chemical class.
What is the primary research target of 5-Amino-1MQ?
The primary published target is nicotinamide N-methyltransferase, or NNMT, an enzyme involved in nicotinamide methylation and methyl-donor metabolism.
What kind of evidence exists for 5-Amino-1MQ?
The product-specific literature is predominantly preclinical, including biochemical, cell-culture and mouse studies. Human therapeutic efficacy has not been established.
Is 5-Amino-1MQ 10mg offered for weight loss or personal use?
No. Tier One supplies this material strictly for laboratory research and does not market it for weight loss, treatment, supplementation, human use or veterinary use.
Canadian Research Procurement
Tier One supplies 5-Amino-1MQ 10mg for qualified Canadian laboratory research. Researchers examining nicotinamide and cellular-energy pathways may also review the Mitochondrial Peptides collection for related research materials. Product-specific identity, purity and analytical statements should be verified from current batch documentation. For research purposes only. Not for human or veterinary use or consumption.
