Melanotan II Canada: 10mg Melanocortin Research
Melanotan II 10mg is supplied in Canada for laboratory research on MT-II, a synthetic cyclic melanocortin peptide derived from the pharmacophore of alpha-melanocyte-stimulating hormone (alpha-MSH). Melanotan II has been widely used in receptor-pharmacology research because it acts as a potent, relatively non-selective agonist across multiple melanocortin receptor subtypes. Tier One lists the material for controlled research use only and does not present it as a cosmetic tanning product, wellness product or treatment.
Quick Research Profile
| Material |
Melanotan II / MT-II |
| Strength |
10mg |
| Research classification |
Synthetic cyclic alpha-MSH analogue / melanocortin receptor agonist peptide |
| Primary research pathways |
Melanocortin receptors including MC1R, MC3R, MC4R and MC5R |
| Research themes |
Receptor binding, receptor activation, melanocortin structure-function and pigment-cell biology |
| Literature status |
Extensive receptor and preclinical literature plus limited historical early-phase human research; no Tier One human-use claim |
| Intended use |
Laboratory research only — not for human or veterinary use |
MT-II and Melanocortin Receptor Pharmacology
MT-II was developed as a cyclic alpha-MSH analogue with high potency at melanocortin receptors. Structure-function studies have examined how the cyclic scaffold and individual residues influence binding and activation at human MC3, MC4 and MC5 receptors, while broader melanocortin research includes MC1R-associated pigment-cell signalling.
MT-II is useful as a characterized melanocortin ligand. Its relative lack of receptor-subtype selectivity is an experimental consideration because a response in a complex model may reflect activity at more than one melanocortin receptor.
Research Areas
Melanocortin receptor binding: MT-II and related analogues have been used to characterize ligand affinity and agonist activity across melanocortin receptor subtypes.
Structure-function research: Analogue studies investigate how cyclization and amino-acid changes alter receptor potency and selectivity.
MC1R and pigment-cell biology: Alpha-MSH-related receptor systems are important in pigmentation biology, but Tier One does not translate that research into tanning or cosmetic-use claims.
Central melanocortin pathways: Experimental work has also used MT-II in models involving MC3R and MC4R signalling. Findings from these models are not evidence of a safe or appropriate personal-use application.
Evidence Quality and Limitations
Melanotan II has a substantial experimental literature as a melanocortin-receptor research ligand, but research findings span receptor assays, animal models and limited historical human studies. Receptor activity does not establish safety, clinical efficacy or suitability for cosmetic use. Tier One makes no claims regarding tanning, appetite, sexual function, treatment, body composition or other human outcomes. Researchers should also distinguish MT-II from other melanocortin analogues with different sequences or receptor-selectivity profiles.
Selected Research References
References are supplied for research context, not as evidence of safety or a recommendation for personal use. Experimental methods, receptor systems, species and material identity should be reviewed directly in the original literature.
Research FAQ: Melanotan II
What is Melanotan II?
Melanotan II, or MT-II, is a synthetic cyclic peptide analogue of alpha-MSH used in melanocortin-receptor pharmacology research.
Which receptors are studied with MT-II?
Research has characterized MT-II at multiple melanocortin receptor subtypes, including MC1R, MC3R, MC4R and MC5R. It is not considered highly subtype-selective.
Is Tier One selling Melanotan II as a tanning product?
No. Tier One supplies Melanotan II strictly as laboratory research material and makes no cosmetic tanning, wellness or personal-use claim.
Does historical human research establish that Melanotan II is safe?
No. Historical early-phase research does not establish broad safety, efficacy or suitability for human use, and Tier One does not make those claims.
Canadian Research Procurement
Tier One supplies Melanotan II 10mg for qualified Canadian laboratory research. Researchers studying peptide-receptor and endocrine signalling can review the Hormone & Endocrine Peptides collection for related materials. Product-specific identity, purity and analytical statements should be verified from current batch documentation. For research purposes only. Not for human or veterinary use or consumption.
